Terminologies and Classifications of Mucocutaneous disorders


Terminologies

ULCER:
Break in the continuity of the surface epithelium of the skin or the mucous membrane to involve the underlying connective tissue as a result of micro molecular cell death of the surface epithelium or its traumatic removal.

VESICLE:
Elevated blister containing clear fluid that is less than 1 cm in diameter.

BULLA:
Elevated blister containing clear fluid that is over 1 cm in diameter.

PAPULES:
These are the lesions raised above the skin or mucosal surface that are smaller than 1 cm in diameter.

NODULES:
These lesions are present within the dermis or mucosa. These lesions may also protrudes above the skin or mucosa forming a characteristic dome shaped structure.

PUSTULES:
These are blisters containing purulent material and appear yellow.

MACULES:
These are the lesions that are flush with adjacent mucosa and that are noticeable because of their difference in color from normal skin or mucosa


Classification of Vesiculobullous lesion

A. Based on Clinical Presentation:
1. Predominantly vesicular:
 HSV infection
 Hand, foot and mouth disease
 Herpangina
 Varicella infection
 Dermatitis herpetiformis

2. Predominantly bullous:
 Pemphigus vulgaris
 Bullous pemphigoid
 Benign mucous membrane pemphigoid
 Erythema multiforme
 Bullous lichen planus
 Epidermolysis bullosa
 Bullous impetigo
 Stevens-johnson syndrome
 Linear IgA disease

B. Histopathological Classification
1. Intraepithelial bullous lesion:
 HSV infection
 Varicella infection
 Herpangina
 Hand foot and mouth disease
 Pemphigus
 Epidermolysis bullosa
 Mucosal erythema multiforme

2. Subepithelial bullous lesions:
 Bullous pemphigoid
 Cicatricial pemphigoid
 Linear IgA disease
 Dermatitis herpetiformis
 Dermal erythema multiforme

C. Etiologic Classification
1. Viral Disease
 Herpetic gingivostomatitis
 Herpetic labialis
 Recurrent Herpes Stomatitis
 Herpangina
 Primary and secondary Varicella Zooster

2. Immunological Conditions
 Pemphigus
 Bullous Pemphigoid
 Erythema Multiforme
 Bullous Lichen Planus

 3. Hereditary Condition
 Epidermolysis Bullosa
 Hailey Hailey Disease
 Daries Disease

4. Miscellaneous Conditions
 Impetigo
 Oral Blood blisters


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